When is the Best Time to Take Meloxicam : Morning or Night? [Detail Guide]

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Take Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation from conditions like osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. It works by blocking cyclooxygenase enzymes which produce prostaglandins that cause inflammation and pain. While meloxicam is effective for relieving symptoms, one common question people have is whether it’s better to take it at night or in the morning. There are pros and cons to both options.

Should I Take Meloxicam At Night Or In The Morning?

Should I Take Meloxicam At Night Or In The Morning?
Should I Take Meloxicam At Night Or In The Morning?

Overview of Meloxicam

  • Meloxicam is sold under brand names like Mobic and Melox. It’s available as a tablet, capsule, and oral suspension.
  • Typical dosing is 7.5 mg to 15 mg taken once daily, depending on the condition being treated.
  • Like other NSAIDs, meloxicam works by inhibiting COX-2 more than COX-1. This provides anti-inflammatory effects with less risk of gastrointestinal side effects.
  • Meloxicam takes 1-2 hours to reach peak concentrations in the blood. Its effects last around 20-24 hours.
  • Common side effects include headache, dizziness, diarrhea, nausea, gas, and upset stomach. More serious side effects are possible.
  • Meloxicam has fewer drug interactions compared to some other NSAIDs. However, combining it with blood thinners, ACE inhibitors, diuretics, and lithium is not recommended.

The Case for Taking Meloxicam at Night

There are some potential benefits to taking meloxicam before bed instead of during the day:

  • May improve sleep: Inflammation and pain can disrupt sleep. Taking meloxicam at night ensures your blood levels are maximal when you’re trying to sleep, which may help improve sleep quality.
  • Convenience: If you take other medications at bedtime, adding meloxicam to your evening routine can simplify your schedule. You don’t have to remember a mid-day dose.
  • May reduce morning stiffness: Many people with arthritis have worse joint stiffness in the morning. Taking meloxicam at night allows the medication to start working while you sleep, potentially minimizing morning stiffness.
  • May cause less daytime drowsiness: Meloxicam can cause dizziness, tiredness, and drowsiness as side effects. Taking it at night limits the chances of daytime drowsiness interfering with work, driving, or other activities.
  • May align better with pain patterns: Some forms of inflammatory arthritis cause more pain at night. Taking meloxicam before bed targets nighttime pain directly.

The Case for Taking Meloxicam in the Morning

On the other hand, there are also some potential advantages to taking meloxicam in the morning:

  • May better cover daytime activities: For people who experience more pain and stiffness during the day, taking meloxicam first thing in the morning helps ensure coverage during waking hours.
  • Easy to remember: Building the habit of taking it in the morning right when you wake up or with breakfast can make it easier to remember your daily dose.
  • Avoid sleep disturbances: While rare, some people may experience insomnia or vivid dreams if they take meloxicam too close to bedtime. Morning dosing avoids this potential issue.
  • Offsets morning stiffness: As mentioned above, morning stiffness is common with inflammatory arthritis. A morning meloxicam dose helps target this directly.
  • Keeps a consistent schedule: If you already take other medications in the morning, taking meloxicam at the same time streamlines your regimen and minimizes confusion.
  • May align better with other treatments: If you do physiotherapy exercises or other treatments in the morning, coordinating meloxicam with these activities can optimize pain relief.
Morning Night
Help with morning stiffness Yes Yes
Help with nighttime pain Somewhat Yes
May improve sleep No Yes
Easy to remember Yes Somewhat
Avoids sleep disturbances Yes No
Aligns with morning exercises Yes No
Avoids daytime drowsiness No Yes
Coverage during waking hours Yes Somewhat

Key Factors to Consider

When deciding between morning or nighttime meloxicam, it’s important to consider:

  • Your individual pain patterns: Pay attention to when your pain and stiffness tend to be worst and tailor timing accordingly.
  • Other medications: Avoid drug interactions and optimize convenience by grouping dosing times.
  • Daily habits and schedule: Pick a routine that works with your lifestyle and will be easiest to stick to consistently.
  • Doctor recommendations: Your doctor may advise specific timing based on your health history and needs. Always follow professional advice.
  • Trial and error: You may need to experiment to see first-hand whether morning or night works better for your symptoms.
  • Long-term use: Timing effects tend to become less pronounced with regular use. Focus more on timing when initially starting meloxicam.

Best Practices for Meloxicam Use

To get the most out of meloxicam while minimizing risks, keep these tips in mind:

  • Take the lowest effective dose based on your doctor’s recommendation. Higher doses carry more side effects.
  • Avoid use with other NSAIDs like aspirin, ibuprofen, or naproxen unless advised by your doctor.
  • Use meloxicam for the shortest duration possible. Long-term use raises safety concerns.
  • Take meloxicam with food to reduce chances of upset stomach.
  • Stay well hydrated while taking meloxicam.
  • Alert your doctor if you experience any concerning side effects.
  • Never exceed 15 mg per day without medical supervision.
  • Discuss safety if you have risk factors like ulcers, kidney disease, heart disease, or high blood pressure.
  • Avoid meloxicam if you have an allergy to aspirin or NSAIDs.

Frequently Asked Questions in Take Meloxicam

Should I take meloxicam at night or morning?

Either morning or night can work, but nighttime tends to be best if you have more pain at night or in the early morning. Take in the AM if you have more daytime pain.

When is the best time to take meloxicam for arthritis?

For arthritis, many doctors recommend taking meloxicam at bedtime to target nighttime pain and morning stiffness. But check with your doctor.

What time of day should meloxicam be taken?

Most experts recommend evening dosing, but morning can work too. Try both ways and see when it works better for your pain patterns.

Should meloxicam be taken with food?

Yes, always take with food. This helps minimize stomach upset.

How long does meloxicam take to work?

It takes 1-2 hours to reach peak blood levels. Effects last for 20-24 hours. It may take a few days of regular doses to experience the full effects.

Can I take meloxicam in the morning and at night?

Never take more than one dose (7.5-15 mg) in a 24 hour period unless specifically instructed by your doctor.

Is it OK to take meloxicam before bed?

Yes, taking it at bedtime is safe and often ideal, especially if you have pain that interferes with sleep or severe morning stiffness.


In summary, while meloxicam can be taken at any time of day, taking it at night offers advantages like improved sleep, reduced morning stiffness, and alignment with pain patterns in conditions like arthritis. However, morning dosing may be preferred if you experience more pain during the day. Pay attention to your specific symptom patterns and medical advice. Most importantly, take meloxicam consistently as directed to manage your inflammation and discomfort.